Our manuscript titled "Single-Molecule Imaging Reveals the Mechanism of Bidirectional Replication Initiation in Metazoa" was officially accepted for publication in Cell. The project started in the summer of 2020 (that first glorious COVID summer) when Scott started imaging how GINS is recruited to replication origins. He later did the same for Cdc45. In 2021 Riki joined the project and focused on imaging firing factors (TopBP1, RecQL4, and finally DONSON). It took a while to explore various hypotheses, sort out various technical difficulties, develop new assays, and develop new tools for analyzing the data. We submitted the paper in November 2023, and after a somewhat bumpy review process, the paper was accepted on 13th of May 2024 :)
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Tomoko, a 1st year CSB graduate student, just started her 2-month rotation in our lab. She will be working with Riki on understanding the mechanism of the CMG helicase activation. We're delighted to double the Japanese contingent of our lab :)
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Please join us in welcoming our new Chistol Lab Admin, Katie Field! While we are sad to see Theresa Lee go, we are fortunate to say that Theresa will continue to support the lab in the background as she introduces Katie to the role, making sure business runs as usual. We appreciate Theresa for her hard work and dedication supporting the lab's functions during these transitional periods.
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The Chistol Lab held its first annual lab retreat on the beautiful pacific coast near Bodega Bay!
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This enclosure gives us precise temperature control, and provides the added benefit of blocking out stray light from the room. See the photos from installation to completion below!
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We spent the day defrosting the freezer to prepare for our move to the Center for Clinical Sciences Research (CCSR) building!
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Lab moments captured during summer 2020.
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We received our first order of the lab's study species, Xenopus laevis!
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Current Category: Life in the Lab
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